Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations

An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting funct...

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Hauptverfasser: Lauring, Josh, Cosgrove, David P., Fontana, Stefani, Gustin, John P., Konishi, Hiroyuki, Abukhdeir, Abde M., Garay, Joseph P., Mohseni, Morassa, Wang, Grace M., Higgins, Michaela, Gorkin, David, Reis, Marcelo, Vogelstein, Bert, Polyak, Kornelia, Cowherd, Meredith, Buckhaults, Phillip J., Park, Ben Ho
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042798/
https://ncbi.nlm.nih.gov/pubmed/20101210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.516
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