PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells

A high frequency of somatic mutations has been found in breast cancers within the gene encoding the catalytic p110α subunit of PI3K, PIK3CA. Using isogenic human breast epithelial cells, we have previously demonstrated that oncogenic PIK3CA “hotspot” mutations predict for response to the toxic effec...

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Hauptverfasser: Higgins, Michaela J, Beaver, Julia A, Wong, Hong yuen, Gustin, John P, Lauring, Josh D, Garay, Joseph P, Konishi, Hiroyuki, Mohseni, Morassa, Wang, Grace M, Cidado, Justin, Jelovac, Danijela, Cosgrove, David P, Tamaki, Akina, Abukhdeir, Abde M, Park, Ben Ho
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047087/
https://ncbi.nlm.nih.gov/pubmed/21124076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.3.14227
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