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PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells
A high frequency of somatic mutations has been found in breast cancers within the gene encoding the catalytic p110α subunit of PI3K, PIK3CA. Using isogenic human breast epithelial cells, we have previously demonstrated that oncogenic PIK3CA “hotspot” mutations predict for response to the toxic effec...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3047087/ https://ncbi.nlm.nih.gov/pubmed/21124076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.3.14227 |
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