PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells

A high frequency of somatic mutations has been found in breast cancers within the gene encoding the catalytic p110α subunit of PI3K, PIK3CA. Using isogenic human breast epithelial cells, we have previously demonstrated that oncogenic PIK3CA “hotspot” mutations predict for response to the toxic effec...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Higgins, Michaela J, Beaver, Julia A, Wong, Hong yuen, Gustin, John P, Lauring, Josh D, Garay, Joseph P, Konishi, Hiroyuki, Mohseni, Morassa, Wang, Grace M, Cidado, Justin, Jelovac, Danijela, Cosgrove, David P, Tamaki, Akina, Abukhdeir, Abde M, Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2011
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047087/
https://ncbi.nlm.nih.gov/pubmed/21124076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.3.14227
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares