PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells

A high frequency of somatic mutations has been found in breast cancers within the gene encoding the catalytic p110α subunit of PI3K, PIK3CA. Using isogenic human breast epithelial cells, we have previously demonstrated that oncogenic PIK3CA “hotspot” mutations predict for response to the toxic effec...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Higgins, Michaela J, Beaver, Julia A, Wong, Hong yuen, Gustin, John P, Lauring, Josh D, Garay, Joseph P, Konishi, Hiroyuki, Mohseni, Morassa, Wang, Grace M, Cidado, Justin, Jelovac, Danijela, Cosgrove, David P, Tamaki, Akina, Abukhdeir, Abde M, Park, Ben Ho
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2011
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3047087/
https://ncbi.nlm.nih.gov/pubmed/21124076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.3.14227
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk