Knockin of mutant PIK3CA activates multiple oncogenic pathways

The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to “knock in” PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epi...

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Hlavní autoři: Gustin, John P., Karakas, Bedri, Weiss, Michele B., Abukhdeir, Abde M., Lauring, Josh, Garay, Joseph P., Cosgrove, David, Tamaki, Akina, Konishi, Hiroyuki, Konishi, Yuko, Mohseni, Morassa, Wang, Grace, Rosen, D. Marc, Denmeade, Samuel R., Higgins, Michaela J., Vitolo, Michele I., Bachman, Kurtis E., Park, Ben Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636736/
https://ncbi.nlm.nih.gov/pubmed/19196980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813351106
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