Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition

D-serine is a physiologic coagonist with glutamate at NMDA-subtype glutamate receptors. As D-serine is localized in glia, synaptically released glutamate presumably stimulates the glia to form and release D-serine, enabling glutamate/D-serine cotransmission. We show that serine racemase (SR), which...

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Main Authors: Mustafa, Asif K., van Rossum, Damian B., Patterson, Randen L., Maag, David, Ehmsen, Jeffrey T., Gazi, Sadia K., Chakraborty, Anutosh, Barrow, Roxanne K., Amzel, L. Mario, Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635840/
https://ncbi.nlm.nih.gov/pubmed/19193859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813105106
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