RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca(2+) release

RACK1 is not a G protein but closely resembles the heterotrimeric Gβ-subunit. RACK1 serves as a scaffold, linking protein kinase C to its substrates. We demonstrate that RACK1 physiologically binds inositol 1,4,5-trisphosphate receptors and regulates Ca(2+) release by enhancing inositol 1,4,5-trisph...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Patterson, Randen L., van Rossum, Damian B., Barrow, Roxanne K., Snyder, Solomon H.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC356950/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14983009/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308567100
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