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Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of d-serine formation
Serine racemase (SR) generates d-serine, a coagonist with glutamate at NMDA receptors. We show that SR is physiologically S-nitrosylated leading to marked inhibition of enzyme activity. Inhibition involves interactions with the cofactor ATP reflecting juxtaposition of the ATP-binding site and cystei...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1815287/ https://ncbi.nlm.nih.gov/pubmed/17293453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611620104 |
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