Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of d-serine formation

Serine racemase (SR) generates d-serine, a coagonist with glutamate at NMDA receptors. We show that SR is physiologically S-nitrosylated leading to marked inhibition of enzyme activity. Inhibition involves interactions with the cofactor ATP reflecting juxtaposition of the ATP-binding site and cystei...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mustafa, Asif K., Kumar, Manish, Selvakumar, Balakrishnan, Ho, Gary P. H., Ehmsen, Jeffrey T., Barrow, Roxanne K., Amzel, L. Mario, Snyder, Solomon H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1815287/
https://ncbi.nlm.nih.gov/pubmed/17293453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611620104
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