Serine Racemase Deletion Protects Against Cerebral Ischemia and Excitotoxicity

d-Serine, formed from l-serine by serine racemase (SR), is a physiologic coagonist at NMDA receptors. Using mice with targeted deletion of SR, we demonstrate a role for d-serine in NMDA receptor-mediated neurotoxicity and stroke. Brain cultures of SR-deleted mice display markedly diminished nitric o...

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Detalhes bibliográficos
Main Authors: Mustafa, Asif K., Ahmad, Abdullah S., Zeynalov, Emil, Gazi, Sadia K., Sikka, Gautam, Ehmsen, Jeffrey T., Barrow, Roxanne K., Coyle, Joseph T., Snyder, Solomon H., Doré, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841469/
https://ncbi.nlm.nih.gov/pubmed/20107067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4297-09.2010
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