A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene

NF1 inactivation occurs in specific human cancers, including juvenile myelomonocytic leukemia, an aggressive myeloproliferative disorder of childhood. However, evidence suggests that Nf1 loss alone does not cause leukemia. We therefore hypothesized that inactivation of the Nf1 tumor suppressor gene...

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Autors principals: Yin, Bin, Delwel, Ruud, Valk, Peter J., Wallace, Margaret R., Loh, Mignon L., Shannon, Kevin M., Largaespada, David A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635073/
https://ncbi.nlm.nih.gov/pubmed/18948576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144436
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