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Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice
Retroviral insertional mutagenesis preferentially identifies oncogenes rather than tumor suppressor (TS) genes, presumably because a single retroviral-induced mutation is sufficient to activate an oncogene and initiate a tumor, whereas two mutations are needed to inactivate a TS gene. Here we show t...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1523184/ https://ncbi.nlm.nih.gov/pubmed/16858412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601215 |
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