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Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice

Retroviral insertional mutagenesis preferentially identifies oncogenes rather than tumor suppressor (TS) genes, presumably because a single retroviral-induced mutation is sufficient to activate an oncogene and initiate a tumor, whereas two mutations are needed to inactivate a TS gene. Here we show t...

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Autori principali: Suzuki, Takeshi, Minehata, Ken-ichi, Akagi, Keiko, Jenkins, Nancy A, Copeland, Neal G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1523184/
https://ncbi.nlm.nih.gov/pubmed/16858412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601215
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