Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy

Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional mutations at LMO2. Genetic evidence also suggests a...

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Detaylı Bibliyografya
Asıl Yazarlar: Davé, Utpal P., Akagi, Keiko, Tripathi, Rati, Cleveland, Susan M., Thompson, Mary A., Yi, Ming, Stephens, Robert, Downing, James R., Jenkins, Nancy A., Copeland, Neal G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2009
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679194/
https://ncbi.nlm.nih.gov/pubmed/19461887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000491
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