Murine Leukemias with Retroviral Insertions at Lmo2 Are Predictive of the Leukemias Induced in SCID-X1 Patients Following Retroviral Gene Therapy

Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional mutations at LMO2. Genetic evidence also suggests a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Davé, Utpal P., Akagi, Keiko, Tripathi, Rati, Cleveland, Susan M., Thompson, Mary A., Yi, Ming, Stephens, Robert, Downing, James R., Jenkins, Nancy A., Copeland, Neal G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679194/
https://ncbi.nlm.nih.gov/pubmed/19461887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000491
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados