Distinct roles of GSK-3α and GSK-3β phosphorylation in the heart under pressure overload

Glycogen synthase kinase-3 (GSK-3) is a master regulator of growth and death in cardiac myocytes. GSK-3 is inactivated by hypertrophic stimuli through phosphorylation-dependent and -independent mechanisms. Inactivation of GSK-3 removes the negative constraint of GSK-3 on hypertrophy, thereby stimula...

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Detalhes bibliográficos
Main Authors: Matsuda, Takahisa, Zhai, Peiyong, Maejima, Yasuhiro, Hong, Chull, Gao, Shumin, Tian, Bin, Goto, Kazumichi, Takagi, Hiromitsu, Tamamori-Adachi, Mimi, Kitajima, Shigetaka, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634936/
https://ncbi.nlm.nih.gov/pubmed/19106302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808315106
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