IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype

Differentiation of murine T-helper (Th) 17 cells is induced by antigenic stimulation and the sequential action of the cytokines IL-6, IL-21, and IL-23, along with TGFβ. Current dogma proposes that IL-6 induces IL-21, which, in a STAT3-dependent manner, amplifies its own transcription, contributes to...

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Main Authors: Huber, Magdalena, Brüstle, Anne, Reinhard, Katharina, Guralnik, Anna, Walter, Gina, Mahiny, Azita, von Löw, Eberhard, Lohoff, Michael
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634912/
https://ncbi.nlm.nih.gov/pubmed/19088203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809077106
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