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IBP (IRF-4 Binding Protein) inhibits IL-17 and IL-21 production by controlling IRF-4 function
The TH17 lineage is a novel CD4(+) T cell effector subset that plays a key role in inflammatory and autoimmune responses, via its ability to produce IL-17 and IL-21. Given the potentially deleterious effects of TH17 cells, their generation needs to be strictly controlled. The regulatory pathways tha...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633410/ https://ncbi.nlm.nih.gov/pubmed/19062315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.10.011 |
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