Loss of IRF-4–binding protein leads to the spontaneous development of systemic autoimmunity

IFN regulatory factor 4–binding (IRF-4–binding) protein (IBP) is a novel type of activator of Rho GTPases that is recruited to the immunological synapse upon TCR stimulation. Here we demonstrate that loss of IBP leads to the spontaneous development of a systemic autoimmune disorder characterized by...

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Detalhes bibliográficos
Main Authors: Fanzo, Jessica C., Yang, Wen, Jang, So Young, Gupta, Sanjay, Chen, Qinzhong, Siddiq, Ayesha, Greenberg, Steven, Pernis, Alessandra B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1361345/
https://ncbi.nlm.nih.gov/pubmed/16470246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24096
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