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IL-17A secretion by CD8(+) T cells supports Th17-mediated autoimmune encephalomyelitis
IL-17–producing CD8(+) T (Tc17) cells are detectible in multiple sclerosis (MS) lesions; however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we induced EAE, a murine model of MS, in mice lacking IFN regulatory factor 4 (IRF4). IRF4-deficient mice failed to gen...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533283/ https://ncbi.nlm.nih.gov/pubmed/23221338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63681 |
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