IL-17A secretion by CD8(+) T cells supports Th17-mediated autoimmune encephalomyelitis

IL-17–producing CD8(+) T (Tc17) cells are detectible in multiple sclerosis (MS) lesions; however, their contribution to the disease is unknown. To identify functions of Tc17 cells, we induced EAE, a murine model of MS, in mice lacking IFN regulatory factor 4 (IRF4). IRF4-deficient mice failed to gen...

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Hauptverfasser: Huber, Magdalena, Heink, Sylvia, Pagenstecher, Axel, Reinhard, Katharina, Ritter, Josephine, Visekruna, Alexander, Guralnik, Anna, Bollig, Nadine, Jeltsch, Katharina, Heinemann, Christina, Wittmann, Eva, Buch, Thorsten, da Costa, Olivia Prazeres, Brüstle, Anne, Brenner, Dirk, Mak, Tak W., Mittrücker, Hans-Willi, Tackenberg, Björn, Kamradt, Thomas, Lohoff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533283/
https://ncbi.nlm.nih.gov/pubmed/23221338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63681
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