2-Methoxyestradiol inhibits experimental autoimmune encephalomyelitis through suppression of immune cell activation

The endogenous metabolite of estradiol, 2-Methoxyestradiol (2ME2), is an antimitotic and antiangiogenic cancer drug candidate that also exhibits disease-modifying activity in animal models of rheumatoid arthritis (RA). We found that 2ME2 dramatically suppresses development of mouse experimental auto...

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Main Authors: Duncan, Gordon S., Brenner, Dirk, Tusche, Michael W., Brüstle, Anne, Knobbe, Christiane B., Elia, Andrew J., Mock, Thomas, Bray, Mark R., Krammer, Peter H., Mak, Tak W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529073/
https://ncbi.nlm.nih.gov/pubmed/23213242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215558110
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