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IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
Differentiation of murine T-helper (Th) 17 cells is induced by antigenic stimulation and the sequential action of the cytokines IL-6, IL-21, and IL-23, along with TGFβ. Current dogma proposes that IL-6 induces IL-21, which, in a STAT3-dependent manner, amplifies its own transcription, contributes to...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2634912/ https://ncbi.nlm.nih.gov/pubmed/19088203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809077106 |
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