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Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity

Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing loss has indicated a possible role for mitochondrial protein...

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Hlavní autoři: Hobbie, Sven N., Akshay, Subramanian, Kalapala, Sarath K., Bruell, Christian M., Shcherbakov, Dmitry, Böttger, Erik C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634874/
https://ncbi.nlm.nih.gov/pubmed/19104050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811258106
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