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Mitochondrial deafness alleles confer misreading of the genetic code

Despite the fact that important genetic diseases are caused by mutant mitochondrial ribosomes, the molecular mechanisms by which such ribosomes result in a clinical phenotype remain largely unknown. The absence of experimental models for mitochondrial diseases has also prevented the rational search...

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Detalhes bibliográficos
Main Authors: Hobbie, Sven N., Bruell, Christian M., Akshay, Subramanian, Kalapala, Sarath K., Shcherbakov, Dmitry, Böttger, Erik C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265171/
https://ncbi.nlm.nih.gov/pubmed/18308926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707265105
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