Binding of Neomycin-Class Aminoglycoside Antibiotics to Mutant Ribosomes with Alterations in the A Site of 16S rRNA

Aminoglycoside antibiotics that bind to the aminoacyl-tRNA site (A site) of the ribosome are composed of a common neamine core in which a glycopyranosyl ring is attached to position 4 of a 2-deoxystreptamine moiety. The core is further substituted by one (ribostamycin), two (neomycin and paromomycin...

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Detalhes bibliográficos
Main Authors: Hobbie, Sven N., Pfister, Peter, Bruell, Christian, Sander, Peter, François, Boris, Westhof, Eric, Böttger, Erik C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426975/
https://ncbi.nlm.nih.gov/pubmed/16569869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1489-1496.2006
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