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Analysis of the Contribution of Individual Substituents in 4,6-Aminoglycoside-Ribosome Interaction
The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycoba...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology
2005
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1315939/ https://ncbi.nlm.nih.gov/pubmed/16304180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.5112-5118.2005 |
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