Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity

Gelijkaardige items

• Synthesis of a Pseudodisaccharide Suitable for Synthesis of Ring I Modified 4,5–2-Deoxystreptamine Type Aminoglycoside Antibiotics.
  door: Sonousi, Amr, et al.
  Gepubliceerd in: (2020)
• Identification and Evaluation of Improved 4′-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics
  door: Duscha, Stefan, et al.
  Gepubliceerd in: (2014)
• Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens
  door: Matsushita, Takahiko, et al.
  Gepubliceerd in: (2019)
• Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics
  door: Sonousi, Amr, et al.
  Gepubliceerd in: (2018)
• N6′, N6‴, and O4′-Modifications to Neomycin Affect Ribosomal Selectivity Without Compromising Antibacterial Activity
  door: Sati, Girish C., et al.
  Gepubliceerd in: (2017)