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Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity

[Image: see text] A series of derivatives of the 4,5-disubstituted class of 2-deoxystreptamine aminoglycoside antibiotics neomycin, paromomycin, and ribostamycin was prepared and assayed for (i) their ability to inhibit protein synthesis by bacterial ribosomes and by engineered bacterial ribosomes c...

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發表在:ACS Infect Dis
Main Authors: Sati, Girish C., Sarpe, Vikram A., Furukawa, Takayuki, Mondal, Sujit, Mantovani, Matilde, Hobbie, Sven N., Vasella, Andrea, Böttger, Erik C., Crich, David
格式: Artigo
語言:Inglês
出版: American Chemical Society 2019
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788953/
https://ncbi.nlm.nih.gov/pubmed/31436080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00128
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