Identification and Evaluation of Improved 4′-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

The emerging epidemic of drug resistance places the development of efficacious and safe antibiotics in the spotlight of current research. Here, we report the design of next-generation aminoglycosides. Discovery efforts were driven by rational synthesis focusing on 4′ alkylations of the aminoglycosid...

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Bibliographic Details
Main Authors: Duscha, Stefan, Boukari, Heithem, Shcherbakov, Dimitri, Salian, Sumantha, Silva, Sandrina, Kendall, Ann, Kato, Takayuki, Akbergenov, Rashid, Perez-Fernandez, Deborah, Bernet, Bruno, Vaddi, Swapna, Thommes, Pia, Schacht, Jochen, Crich, David, Vasella, Andrea, Böttger, Erik C.
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196235/
https://ncbi.nlm.nih.gov/pubmed/25271289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01827-14
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