Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

Aminoglycosides are potent antibacterials, but therapy is compromised by substantial toxicity causing, in particular, irreversible hearing loss. Aminoglycoside ototoxicity occurs both in a sporadic dose-dependent and in a genetically predisposed fashion. We recently have developed a mechanistic conc...

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Detalles Bibliográficos
Autores principales: Matt, Tanja, Ng, Chyan Leong, Lang, Kathrin, Sha, Su-Hua, Akbergenov, Rashid, Shcherbakov, Dmitri, Meyer, Martin, Duscha, Stefan, Xie, Jing, Dubbaka, Srinivas R., Perez-Fernandez, Déborah, Vasella, Andrea, Ramakrishnan, V., Schacht, Jochen, Böttger, Erik C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390888/
https://ncbi.nlm.nih.gov/pubmed/22699498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204073109
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