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Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye

PURPOSE: In an earlier study we found normal adeno-associated viral vector type 2 (AAV2)-mediated GFP expression after intravitreal injection to one eye of normal C57BL/6J mice. However, GFP expression was very poor in the partner eye of the same mouse if this eye received an intravitreal injection...

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Hlavní autoři: Li, Wensheng, Kong, Fansheng, Li, Xia, Dai, Xufeng, Liu, Xiaoqiang, Zheng, Qinxiang, Wu, Ronghan, Zhou, Xiangtian, Lü, Fan, Chang, Bo, Li, Qiuhong, Hauswirth, William W., Qu, Jia, Pang, Ji-jing
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Vision 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633462/
https://ncbi.nlm.nih.gov/pubmed/19190735
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