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RNA major groove modifications improve siRNA stability and biological activity
RNA 5-methyl and 5-propynyl pyrimidine analogs were substituted into short interfering RNAs (siRNAs) to probe major groove steric effects in the active RNA-induced silencing complex (RISC). Synthetic RNA guide strands containing varied combinations of propynyl and methyl substitution revealed that a...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2632910/ https://ncbi.nlm.nih.gov/pubmed/19042976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn958 |
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