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CAN OLIGOMERIC T-CELL RECEPTOR BE USED AS A TOOL TO DETECT VIRAL PEPTIDE EPITOPES ON INFECTED CELLS?

We have utilized soluble HIV Gag-specific T-cell receptor (TCR) D3 with low affinity and TCR-like antibody 25-D1.16 recognizing its natural peptide-MHC (pMHC) ligand with high affinity to determine how affinity and off-rate of the receptor-pMHC interactions affect the sensitivity of pMHC detection o...

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Detalhes bibliográficos
Main Authors: Anikeeva, Nadia, Mareeva, Tatiana, Liu, Wei, Sykulev, Yuri
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632680/
https://ncbi.nlm.nih.gov/pubmed/18845488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2008.08.025
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