Development of a Rab9 Transgenic Mouse and Its Ability to Increase the Lifespan of a Murine Model of Niemann-Pick Type C Disease

Niemann-Pick, type C (NP-C) disease is an autosomal recessive neurovisceral storage disorder in which cholesterol and sphingolipids accumulate. There is no specific treatment for this disease, which is characterized by progressive neurological deterioration, sometimes accompanied by hepatosplenomega...

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Detalhes bibliográficos
Main Authors: Kaptzan, Tatiana, West, Sally A., Holicky, Eileen L., Wheatley, Christine L., Marks, David L., Wang, Tengke, Peake, Kyle B., Vance, Jean, Walkley, Steven U., Pagano, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631314/
https://ncbi.nlm.nih.gov/pubmed/19056848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080660
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