Development of a Rab9 Transgenic Mouse and Its Ability to Increase the Lifespan of a Murine Model of Niemann-Pick Type C Disease

Niemann-Pick, type C (NP-C) disease is an autosomal recessive neurovisceral storage disorder in which cholesterol and sphingolipids accumulate. There is no specific treatment for this disease, which is characterized by progressive neurological deterioration, sometimes accompanied by hepatosplenomega...

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Главные авторы: Kaptzan, Tatiana, West, Sally A., Holicky, Eileen L., Wheatley, Christine L., Marks, David L., Wang, Tengke, Peake, Kyle B., Vance, Jean, Walkley, Steven U., Pagano, Richard E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2009
Предметы:
Short Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631314/
https://ncbi.nlm.nih.gov/pubmed/19056848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080660
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