Development of a Rab9 Transgenic Mouse and Its Ability to Increase the Lifespan of a Murine Model of Niemann-Pick Type C Disease

Niemann-Pick, type C (NP-C) disease is an autosomal recessive neurovisceral storage disorder in which cholesterol and sphingolipids accumulate. There is no specific treatment for this disease, which is characterized by progressive neurological deterioration, sometimes accompanied by hepatosplenomega...

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Bibliografiska uppgifter
Huvudupphovsmän: Kaptzan, Tatiana, West, Sally A., Holicky, Eileen L., Wheatley, Christine L., Marks, David L., Wang, Tengke, Peake, Kyle B., Vance, Jean, Walkley, Steven U., Pagano, Richard E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2009
Ämnen:
Short Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2631314/
https://ncbi.nlm.nih.gov/pubmed/19056848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080660
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