Lymphocyte-Specific Compensation For XLF/Cernunnos End-Joining Functions In V(D)J Recombination

Mutations in XLF/Cernunnos (hereafter called "XLF") cause lymphocytopenia in humans, and various studies suggest an XLF role in classical non-homologous end joining (C-NHEJ). We now find that XLF-deficient mouse embryonic fibroblasts are ionizing radiation (IR) sensitive and severely impai...

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Main Authors: Li, Gang, Alt, Frederick W., Cheng, Hwei-Ling, Brush, James W., Goff, Peter, Murphy, Mike M., Franco, Sonia, Zhang, Yu, Zha, Shan
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630261/
https://ncbi.nlm.nih.gov/pubmed/18775323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.07.017
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