Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) (PLG) and polystyrene microparticles, dramatically enhance secretion of in...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Sharp, Fiona A., Ruane, Darren, Claass, Benjamin, Creagh, Emma, Harris, James, Malyala, Padma, Singh, Manomohan, O'Hagan, Derek T., Pétrilli, Virginie, Tschopp, Jurg, O'Neill, Luke A. J., Lavelle, Ed C.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2009
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630092/
https://ncbi.nlm.nih.gov/pubmed/19139407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804897106
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