MAGE-11 inhibits the hypoxia-inducible factor prolyl hydroxylase PHD2 and activates hypoxic response

Activation of hypoxia-inducible factors (HIFs), responsible for tumor angiogenesis and glycolytic switch, is regulated by reduced oxygen availability. Normally, HIF-α proteins are maintained at low levels, controlled by site-specific hydroxylation carried out by HIF prolyl hydroxylases (PHDs), and s...

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Bibliographic Details
Main Authors: Aprelikova, Olga, Pandolfi, Silvia, Tackett, Sean, Ferreira, Mark, Salnikow, Konstantin, Ward, Yvona, Risinger, John I., Barrett, J.Carl, Niederhuber, John
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629394/
https://ncbi.nlm.nih.gov/pubmed/19147576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0811
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