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Structural basis for selectin mechanochemistry

Selectins are adhesion molecules that resist large tensile forces applied by hydrodynamic forces to leukocytes binding to vessel walls. In crystals, the liganded (high-affinity) and unliganded (low-affinity) conformations differ in orientation between their tandem lectin and EGF domains. I examine h...

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Библиографические подробности
Главный автор: Springer, Timothy A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629181/
https://ncbi.nlm.nih.gov/pubmed/19118197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810784105
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