Engineered Protein Connectivity to Actin Mimics PDZ-dependent Recycling of G Protein-coupled Receptors but Not Its Regulation by Hrs

Many G protein-coupled receptors (GPCRs) recycle after agonist-induced endocytosis by a sequence-dependent mechanism, which is distinct from default membrane flow and remains poorly understood. Efficient recycling of the β2-adrenergic receptor (β2AR) requires a C-terminal PDZ (PSD-95/Discs Large/ZO-...

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Detalhes bibliográficos
Main Authors: Lauffer, Benjamin E. L., Chen, Stanford, Melero, Cristina, Kortemme, Tanja, von Zastrow, Mark, Vargas, Gabriel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629119/
https://ncbi.nlm.nih.gov/pubmed/19001361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806370200
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