HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein

The HIV-1 Gag protein recruits the cellular factor Tsg101 to facilitate the final stages of virus budding. A conserved P(S/T)AP tetrapeptide motif within Gag (the “late domain”) binds directly to the NH(2)-terminal ubiquitin E2 variant (UEV) domain of Tsg101. In the cell, Tsg101 is required for biog...

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Main Authors: Pornillos, Owen, Higginson, Daniel S., Stray, Kirsten M., Fisher, Robert D., Garrus, Jennifer E., Payne, Marielle, He, Gong-Ping, Wang, Hubert E., Morham, Scott G., Sundquist, Wesley I.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172688/
https://ncbi.nlm.nih.gov/pubmed/12900394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302138
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