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Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is well known to terminate cell signaling by sorting activated receptors to the MVB/lysosomal pathway. Here we identify a distinct role of Hrs in promoting rapid recycling of endocytosed signaling receptors to the plasma membrane. Th...

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Detalhes bibliográficos
Main Authors: Hanyaloglu, Aylin C, McCullagh, Emma, von Zastrow, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1173141/
https://ncbi.nlm.nih.gov/pubmed/15944737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600688
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