IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13

BACKGROUND: IL-13 is a critical mediator of allergic asthma and associated airway hyperresponsiveness. IL-13 acts through a receptor complex comprised of IL-13Rα1 and IL-4Rα subunits with subsequent activation of signal transducer and activator of transcription 6 (STAT6). The IL-13Rα2 receptor may a...

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Main Authors: Moynihan, Barry J, Tolloczko, Barbara, Bassam, Souad El, Ferraro, Pascale, Michoud, Marie-Claire, Martin, James G, Laberge, Sophie
格式: Artigo
語言:Inglês
出版: BioMed Central 2008
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628656/
https://ncbi.nlm.nih.gov/pubmed/19116009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-9-84
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