Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

Cullin-RING Ligases (CRLs) comprise the largest ubiquitin E3 subclass, in which a central cullin subunit links a substrate-binding adaptor with an E2-binding RING. Covalent attachment of the ubiquitin-like protein NEDD8 to a conserved C-terminal domain (ctd) lysine stimulates CRL ubiquitination acti...

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Bibliographic Details
Main Authors: Duda, David M., Borg, Laura A., Scott, Daniel C., Hunt, Harold W., Hammel, Michal, Schulman, Brenda A.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628631/
https://ncbi.nlm.nih.gov/pubmed/18805092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.022
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