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Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
Cullin-RING Ligases (CRLs) comprise the largest ubiquitin E3 subclass, in which a central cullin subunit links a substrate-binding adaptor with an E2-binding RING. Covalent attachment of the ubiquitin-like protein NEDD8 to a conserved C-terminal domain (ctd) lysine stimulates CRL ubiquitination acti...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628631/ https://ncbi.nlm.nih.gov/pubmed/18805092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.07.022 |
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