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Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

Menaquinone (vitamin K(2)) is an essential component of the electron transfer chain in many pathogens, including Mycobacterium tuberculosis and Staphylococcus aureus, and menaquinone biosynthesis is a potential target for antibiotic drug discovery. We report herein a series of mechanism-based inhibi...

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Detalhes bibliográficos
Main Authors: Lu, Xuequan, Zhang, Huaning, Tonge, Peter J., Tan, Derek S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628629/
https://ncbi.nlm.nih.gov/pubmed/18762421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.07.130
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