Stable Analogues of OSB-AMP: Potent Inhibitors of MenE, the o-Succinylbenzoate-CoA Synthetase from Bacterial Menaquinone Biosynthesis

MenE, the o-succinylbenzoate (OSB)-CoA synthetase from bacterial menaquinone biosynthesis, is a promising new antibacterial target. Sulfonyladenosine analogues of the cognate reaction intermediate, OSB-AMP, have been developed as inhibitors of the MenE enzymes from Mycobacterium tuberculosis (mtMenE...

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Bibliografiske detaljer
Main Authors: Lu, Xuequan, Zhou, Rong, Sharma, Indrajeet, Li, Xiaokai, Kumar, Gyanendra, Swaminathan, Subramanyam, Tonge, Peter J., Tan, Derek S.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436903/
https://ncbi.nlm.nih.gov/pubmed/22109989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100585
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