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Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics
[Image: see text] A stereoselective synthesis has been developed to provide all four side-chain stereoisomers of difluoroindanediol 2, the mixture of which was previously identified as an inhibitor of the o-succinylbenzoate-CoA synthetase MenE in bacterial menaquinone biosynthesis, having promising...
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| Wydane w: | Org Lett |
|---|---|
| Główni autorzy: | , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American
Chemical Society
2016
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5171203/ https://ncbi.nlm.nih.gov/pubmed/27978658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b03272 |
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