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Evaluating the potency of HIV-1 protease drugs to combat resistance

HIV-1 protease has been an important drug target for the antiretroviral treatment of HIV infection. The efficacy of protease drugs is impaired by the rapid emergence of resistant virus strains. Understanding the molecular basis and evaluating the potency of an inhibitor to combat resistance are no d...

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Bibliografiske detaljer
Main Authors: Hou, Tingjun, McLaughlin, William A., Wang, Wei
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628484/
https://ncbi.nlm.nih.gov/pubmed/18004760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.21808
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