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Evaluating the potency of HIV-1 protease drugs to combat resistance

HIV-1 protease has been an important drug target for the antiretroviral treatment of HIV infection. The efficacy of protease drugs is impaired by the rapid emergence of resistant virus strains. Understanding the molecular basis and evaluating the potency of an inhibitor to combat resistance are no d...

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Detalhes bibliográficos
Main Authors: Hou, Tingjun, McLaughlin, William A., Wang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628484/
https://ncbi.nlm.nih.gov/pubmed/18004760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.21808
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