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Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines

5-aza-2′-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes, but resistance to this agent is common. In search for mechanisms of resistance, we measured the half maximal (50%) inhibitory concentration (IC(50)) of DAC and found it differed 1000-fold among a panel of cancer...

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Bibliografski detalji
Glavni autori: Qin, Taichun, Jelinek, Jaroslav, Si, Jiali, Shu, Jingmin, Issa, Jean-Pierre J.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628372/
https://ncbi.nlm.nih.gov/pubmed/18931345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-140038
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