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Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell lines
5-aza-2′-deoxycytidine (DAC) is approved for the treatment of myelodysplastic syndromes, but resistance to this agent is common. In search for mechanisms of resistance, we measured the half maximal (50%) inhibitory concentration (IC(50)) of DAC and found it differed 1000-fold among a panel of cancer...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628372/ https://ncbi.nlm.nih.gov/pubmed/18931345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-140038 |
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