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Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development
Allelic exclusion of Ig gene expression is necessary to limit the number of functional receptors to one per B cell. The mechanism underlying allelic exclusion is unknown. Because germline transcription of Ig and TCR loci is tightly correlated with rearrangement, we created two novel knock-in mice th...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626736/ https://ncbi.nlm.nih.gov/pubmed/19116268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808895106 |
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